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DoD funds development of anthrax vaccine patch

first_imgApr 8, 2008 (CIDRAP News) – Iomai Corp., a biotechnology company that specializes in needle-free vaccines, announced today that it will receive a grant from the US Department of Defense (DoD) to fund preclinical development of a patch-based anthrax vaccine.The 1-year grant to Iomai, based in Gaithersburg, Md., will be in the form of a $943,856 cost reimbursement from the US Army Medical Research and Material Command, according to a press release from Iomai.Work on the vaccine will combine an antigen developed by Avecia Biologics, Ltd., based in the United Kingdom, with an Iomai adjuvant on a skin patch. Iomai said its next step would be to gauge the stability of the patch to see if it can be stored and shipped at room temperature.The current licensed anthrax vaccine, made by Emergent BioSolutions Inc., must be refrigerated and is given as a six-shot regimen over 18 months. The US government has been seeking a second-generation product to replace anthrax vaccine adsorbed (AVA), developed in the 1950s, with hopes that a newer product would require fewer doses and produce minimal side effects. Some military personnel have objected to AVA because of reported serious side effects.”The military has a clear need for an effective anthrax vaccine that can be stockpiled and shipped at room temperature, and we believe that Iomai has the scientific know-how and the manufacturing ability to meet that need,” said Stanley C. Erck, Iomai’s president and chief executive officer, in the press release.Iomai says it has developed techniques for drying proteins, such as the anthrax vaccine, to allow administration with a patch the size of an adhesive bandage. The company says it has four other products using the protein-drying technology in its development pipeline; three are aimed at seasonal and pandemic influenza and the other at travelers’ diarrhea.On Apr 2, PharmAthene, an Annapolis, Md., biodefense company, announced that it had finalized its acquisition of the biodefense vaccine business of Avecia, Iomai’s anthrax vaccine partner. Iomai acknowledged the sale in its press release but did not give any details about how it would affect preclinical work on the anthrax vaccine patch.PharmAthene, in its press release, said it had acquired all of the assets related to Avecia’s vaccines business, including intellectual property rights to its recombinant protective antigen (rPA) anthrax vaccine and plague vaccine, as well as government contracts relating to the vaccines that total $60 million.Avecia has completed phase 2 clinical studies of its rPA anthrax vaccine, according to PharmAthene. In February, the US Department of Health and Human Services (HHS) issued a request for proposals for an anthrax rPA vaccine for the Strategic National Stockpile (SNS), the company said in its press release. The HHS proposal request calls for a company to produce 25 million doses of anthrax vaccine.On Mar 24, the Wall Street Journal reported that the government’s anthrax vaccine contract could be worth more than $400 million.David P. Wright, PharmAthene’s president and chief executive officer, said in the press release that preclinical and clinical studies of Avecia’s anthrax vaccine show an antibody response and that it is safe and well tolerated.”If these results are confirmed in future studies, we believe this vaccine could prove to be a superior choice for procurement in the Strategic National Stockpile for civilian defense against anthrax threats,” he said.Federal officials have hit roadblocks in their efforts to add a second-generation anthrax vaccine to the national stockpile. In December 2006, HHS canceled an $877 million contract with VaxGen, a small biotechnology company based in Brisbane, Calif., after the company had problems with its vaccine’s stability and missed a deadline for starting a clinical trial.In October 2007, a report from the Government Accountability Office (GAO) criticized federal anthrax vaccine procurement efforts, saying officials awarded the contract prematurely, had unrealistic expectations of VaxGen, and were confused about how the vaccine would be used.See also:Apr 8 Iomai press releaseApr 2 PharmAthene press release Oct 31, 2007, CIDRAP News story “GAO critiques anthrax vaccine procurement, management”last_img read more

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NBBF commends IOC for 2020 Olympics postponement

first_imgRelatedPosts Serbia-based Nigerian basketballer slumps, dies after training NBBF celebrates Nigerian Arizona Women Basketball player of the Decade Pray for Nigeria during Ramadan — NBBF The leadership of the Nigeria Basketball Federation has commended the International Olympics Committee’s decision to postpone the Tokyo Summer Olympics for another one year as the world combats the coronavirus pandemic. In a statement issued by the NBBF President, Engr. Musa Kida, he commended the IOC for taking such a bold but difficult decision to postpone an iconic event for the good and safety of the world. According to him, this is one of the major decisions taken across the globe necessary for tackling the pandemic that has continued to threaten human existence. Kida said: “Postponement of the 2020 Tokyo Olympics is the right step taken at such a critical time because as the saying goes, nothing is worth human life. “We know this decision will come at an additional cost to sponsors, vendors, the government of Japan, participating countries and their athletes, but it is a necessary step.” Kida said if we have to protect the human existence as it is currently known, there is need for governments around the world to come around, unite and fight the pandemic, which till now has no known cure. He said: “It is crucial for basketball players in Nigeria and abroad to know the importance of social distancing and self-quarantine as being promoted by the World Health Organisation and medical personnel as a key step in breaking the chain of the viral infection. “At this crucial time, we must realise that only those who are alive can play basketball. “We must place premium value on our lives and pay attention to our hygiene. “Constantly washing of hands and the use of sanitizers can also stem the spread.” Kida said being socially responsible will make the world a better place and reduce the spread of the viral infection. The senior basketball men and women teams of Nigeria have qualified for the 2020 Olympics earlier scheduled for the iconic city of Tokyo between July 24 and August 9, 2020.Tags: 2020 Olympics PostponementNBBFlast_img read more

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David Warner’s constant poking spurred me on Stokes

first_imgLondon: England all-rounder Ben Stokes has revealed that it was David Warner’s constant efforts to break his concentration that egged him on further en route his epic unbeaten 135 in the Ashes Headingly Test.“I had extra personal motivation due to some things that were said to me out on the field on the evening of day three when I was trying to get through to stumps,” Stokes revealed in an extract published in Daily Mirror.“A few of the Aussies were being quite chirpy, but in particular David Warner seemed to have his heart set on disrupting me,” he said.“He just wouldn’t shut up for most of my time out there. I could accept it from just about any other opponent. Truly. Not from him, though.“The changed man he was adamant he’d become, the one that hardly said boo to a goose and even went as far as claiming he had been re-nicknamed ‘Humble’ by his Australia teammates, had disappeared. Maybe his lack of form in his new guise had persuaded him that he needed to get the bull back,” he added.Stokes helped England snatch victory from the jaws of defeat with that epic knock as England squared the five-match series at 1-1.England was shot out for 67 in the first innings and were 286-9, still needing 73 more runs to win with a target of 359 when No. 11 Jack Leach walked out to bat and joined Stokes at the crease to share a historic stand and take England over the line.Talking more about how Warner tried to get under his skin, Stokes said the fact that the southpaw did not get runs in the Ashes put him under more pressure to contribute in some way.“Although he’d enjoyed a prolific World Cup campaign, he had struggled with the bat at the start of the Ashes and was perhaps turning to his old ways to try to get the best out of himself. The nice-guy act had done nothing for his runs column.“I muttered ‘Bloody Warner’ a few times as I was getting changed. The more time passed, the more it spurred me on. All kinds of ideas of what I might say to him at the end of the game went through my head. In the end, I vowed to do nothing other than shake his hand and say ‘Well done’ if I could manufacture the situation.“You always shake the hands of every member of the opposing team at the end of a match. But this one would give me the greatest sense of satisfaction,” he said. IANSAlso Read: David Warner’s daughter wants to be Indian captain like Virat KohliAlso Watch: India’s First PM Jawaharlal Nehru’s 130th Birth Anniversary observedlast_img read more

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