Share Facebook Twitter Google + LinkedIn Pinterest The outlook for November calls for temperatures and rainfall above normal.It appears we will see a series of weak weather systems the next two weeks. Most of the state will be at or below normal rainfall into the start of November. However, the far northern tier of Ohio will see normal to above normal rainfall putting pressure on wet conditions and challenge harvest in the far north and northeast part of the state.After a start to November not really wet except far north, most climate models indicate a return to a more active weather pattern for middle and later November. Along with the wetter pattern will come temperatures several degrees above normal.Most areas will see the delayed freeze that was forecast for many months come to pass in early November, a few weeks behind schedule.The outlook for winter calls for near normal temperatures and slightly above normal precipitation.Early indications for next planting season in spring call for near normal temperatures and slightly above normal precipitation.Over the next two weeks, the NOAA/NWS/Ohio River Forecast Center 16-day weather models mean rainfall is around an inch in southern Ohio to three plus inches in far northern Ohio.
Related Posts A Web Developer’s New Best Friend is the AI Wai… Tags:#Apple#Steve Jobs The much-anticipated biopic of Apple founder Steve Jobs – “jOBS” – starring Ashton Kutcher is set to make its debut tonight at the Sundance Film Festival. Today we get our first sneak peek in one minute scene of Kutcher and Josh Gads, who plays a beatnik-geek version of Apple co-founder Steve Wozniak, discussing the potential for the first personal computer.“Nobody wants to buy a computer, nobody,” Wozniak says.“How does somebody know what they want if they have never even seen it,” Jobs says.Wozniak’s line is akin to the sentiment expressed by IBM CEO Thomas Watson at the time who imfamously said, “I think there is a world market for maybe five computers.” History would, epically, prove Watson wrong. See the one minute clip below. “jOBS” is set to hit theaters on April 19th. Why Tech Companies Need Simpler Terms of Servic… Top Reasons to Go With Managed WordPress Hosting dan rowinski 8 Best WordPress Hosting Solutions on the Market
New Delhi has told the Bru (or Reang) refugees in Tripura to either accept a rehabilitation package and return to their villages in adjoining Mizoram or give up the free rations and other facilities being provided to them on humanitarian grounds.Satyendra Garg, Joint Secretary (Northeast) in the Ministry of Home Affairs, had on Monday met senior Mizoram government officials and Bru leaders in Aizawl. Appealing to the refugees to return to Mizoram, he said the names of those who wished to be repatriated would be submitted to the Centre and the Mizoram government, while reminding that the ration and other facilities extended to the refugees would be withdrawn from October 1.The option has not gone down well with a section of the refugees who have threatened to launch an agitation to choke the roads leading to Mizoram. “We have been used to such threats [for stopping of ration] for more than 20 years now. The government wants to dictate terms even if it means pushing the refugees into uncertainty. We won’t take things lying down,” said Laldingliana, president of the Mizoram Bru Displaced People’s Coordination Committee.Agreement with refugeesThere are at least three groups representing the refugees. The Centre had in July signed an agreement with one of them – Mizoram Bru Displaced People’s Forum – apart from the Mizoram and Tripura governments for repatriation of some 32,000 Brus to Mizoram by September 30 this year. But a large number of refugees have refused to budge unless some new demands are met. These include creation of an area development council for the minority Brus in Mizoram and payment of one-time Central assistance of ₹4 lakh per family before going back, and repatriation of all in a cluster of villages for security reasons.According to the July agreement, each Bru refugee family would be given ₹4 lakh, to be kept in fixed deposit, within one month of repatriation.‘Not enough’“The Government seems generous by saying it is free ration that it is providing us. Each refugee gets 7 grams of salt per day and a pair of slippers once in three years. A male gets a shirt and a female a skirt annually. Financial assistance for an adult is ₹5 and for a minor ₹2.5 per day, while an adult gets 600 gm of rice and a minor 300 gm per day. These have never been enough, forcing us to do odd jobs for a living,” Mr. Laldingliana.Another group, the Bru Coordination and Equal Package Demand Committee, representing some 8,000 Brus who have already returned to Mizoram, too has raised some demands. “Those who came back accepting small packages earlier should also be given the kind of compensation others are slated to receive,” Committee’s leader Elvis Chorkhy said.More than 40,000 Brus had fled Mizoram, mostly from Mamit district to Tripura, during ethnic clashes with the dominant Mizos in 1997.
Private companies step in to help SEA Games hosting Pogoy hit a triple with 43 seconds left for five-point lead and then sealed the deal with two free throws with 2.6 ticks to play as the Texters finally broke their silence while dealing the Road Warriors a third straight defeat.TNT was leading comfortably going into the latter half of the fourth period when the Road Warriors–who incidentally lost coach Yeng Guiao to two technical fouls a few minutes before–mounted a last-minute charge with Poy Erram leading the way.FEATURED STORIESSPORTSPrivate companies step in to help SEA Games hostingSPORTSUrgent reply from Philippine football chiefSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool starsErram hit three straight baskets that had the Road Warriors creeping within 79-77, and then had a triple after that Pogoy trey to make it 80-82 going into the final 35 seconds only for NLEX to fail to execute in their next offensive. Oil plant explodes in Pampanga town Lacson backs proposal to elect president and vice president in tandem Grace Poe files bill to protect govt teachers from malicious accusations MOST READ Sports Related Videospowered by AdSparcRead Next LATEST STORIES US judge bars Trump’s health insurance rule for immigrants RR Pogoy dropped the biggest points in the stretch on Wednesday night and saved TNT KaTropa from imploding, with an 85-80 nipping of NLEX giving the Texters their first win in the PBA Philippine Cup eliminations at Smart Araneta Coliseum in Cubao.ADVERTISEMENT PH underwater hockey team aims to make waves in SEA Games PLAY LIST 02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games02:11Trump awards medals to Jon Voight, Alison Krauss SEA Games hosting troubles anger Duterte Olympic champion among 4 Thai weightlifters to test positive ‘We are too hospitable,’ says Sotto amid SEA Games woes Oil plant explodes in Pampanga town Don’t miss out on the latest news and information. View comments
WILMINGTON, MA — According to the National Center for Missing & Exploited Children, a Wilmington teenager has been missing since May 19, 2018.Kathrine Morona, who also went missing in March and was found safe, is a 16-year-old Hispanic female with black hair and brown eyes. She is 5’3″ and 130 pounds. Her nose is pierced and may be wearing glasses. Kathrine may be in the company of an adult male.If seen, please call 911, 1-800-THE-LOST, or the Wilmington Police Department at 978-658-5071.Kathrine MoronaLike Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email email@example.com.Share this:TwitterFacebookLike this:Like Loading… RelatedMISSING CHILD: Have You Seen This Wilmington Teen?In “Government”BREAKING NEWS: Have You Seen This 14-Year-Old Girl Missing From Wilmington?In “Breaking”PHOTO OF THE DAY: Have You Seen These 2 Missing Billerica Children?In “Photo of the Day”
WILMINGTON, MA — Wilmington High Athletic Director Tim Alberts recently announced that 24 Wilmington High student athletes were named Middlesex League All-Star this spring:BaseballCarl BeatriceDan GraciaChris GreccoMatt RideoutGirls LacrosseOlivia CarpenitoBoys LacrosseTyler RobertsSoftballAdele BurtonDana GouletAntonia KieranAlly Moran (League MVP)Girls TennisKrista BrownJessica D’ArcoEmily HillLia KourkoutasGirls Track & FieldJade BrennanEmma GarrityHannah LavitaAlexcia LunaEvelyn Miller-NuzzoAmie RussellBoys Track & FieldSean BrazNolan KaneJohn KenneySam VinceLike Wilmington Apple on Facebook. Follow Wilmington Apple on Twitter. Follow Wilmington Apple on Instagram. Subscribe to Wilmington Apple’s daily email newsletter HERE. Got a comment, question, photo, press release, or news tip? Email firstname.lastname@example.org.Share this:TwitterFacebookLike this:Like Loading… Related35 WHS Student Athletes Named Middlesex League All-Stars This SpringIn “Sports”Athletic Director Tim Alberts Departs Wilmington For TritonIn “Education”22 WHS Student Athletes Named Middlesex League All-Stars This SpringIn “Sports”
$179 Mentioned Above Apple TV 4K (32GB) CNET may get a commission from retail offers. 1:49 $169 Comments See It Best Buy If you have a bootleg streaming device, chances are it’s filled with malware, researchers found. Sarah Tew/CNET It seems there’s no such thing as a free show.Security researchers from the Digital Citizens Alliance (DCA) and Dark Wolfe Consulting looked into six streaming devices that offered free shows through pirated apps and found nearly half of them were packed with malware. While you may have bought a bona fide Apple TV or Roku to watch shows on Netflix or Hulu, there’s an entire market online for jailbroken and modified devices that are tuned to watch this same content for free. They come at a much cheaper price and offer free, unlimited access to shows that you’d normally have to pay a subscription fee for. These devices work just like a Roku or a Fire TV Stick — you plug it into your TV and connect it to your Wi-Fi network. In some cases, they’re loaded with apps. 7 Now playing: Watch this: The DCA and Dark Wolfe found that there were 12 million active users in the US with these devices, meaning that millions of people are exposed to malware packed with these free shows, according to a report DCA published Thursday. “You have a choice, you can either have free movies, or your bank account,” said Tom Galvin, the DCA’s executive director. “When you bring one of these into your home, you’ve escorted a hacker past your security.” One app for pirated movies and live sports, called Mobdro, immediately forwarded his Wi-Fi network name and password to servers in Indonesia, he said. Other apps would collect data on the user, including photos and videos on the network, and upload them to the server. In one case, an app collected more than a terabyte of data after getting connected to Wolfe’s network. These apps offered streams on movies that were still in theaters during the study time, like Aquaman and Green Book, as well as access to pay-per-views like UFC fights. One app, called “Free Netflix,” used a network of stolen Netflix accounts that would constantly rotate so that hacked users would not become suspicious, Wolfe said.In the background, these apps were scanning victims’ networks, looking for open ports to infect other devices, he said. “Once you start using these rogue apps, nothing is free, there’s always some angle to them,” Wolfe said. In one case, when the DCA arranged to buy one of the devices off Craigslist, the seller came out of the Department of Labor building in Washington, DC, to hand off the goods. On hacker forums, the researchers found that criminals online were discussing ways to exploit this malware. “Streaming is where consumers go to for their home entertainment, which means hackers and criminals are now targeting streaming as a place to exploit consumers,” Galvin said. $179 Apple See it See It Crutchfield Tags If the hardware isn’t laced with malware, the apps are, Timber Wolfe, a principal at Dark Wolfe Consulting, found in his research. He said 40% of apps for these devices were infected with malware that can take over a camera or microphone on the network within the first hour.As viewers move to streaming devices to watch shows, like Apple TVs, Rokus, Chromecasts and Fire TVs, black market sellers have capitalized on cordcutters by offering pirated alternatives. Cybercriminals have taken notice, by targeting these bootleg boxes with malware, researchers found. On April 8, the FCC issued an enforcement advisory warning that they were fining up to $19,639 per day for people selling these illegal streaming boxes, as well as people using them. While they aren’t in stores, you can still find them in popular sites like eBay, Craigslist and Facebook Marketplace. They’re also often sold at flea markets and malls for about $75 to $100. People are enticed to buy them because they promise free streams on sports, live shows and new movies. Once you start using these rogue apps, nothing is free, there’s always some angle to them. Timber Wolfe, Dark Wolfe Consulting Those bootleg streaming devices have malware preinstalled Review • Apple TV 4K review: The best TV streamer keeps getting better Malware Share your voice See It $179 Apple TV 4K TV and Movies Security Preview • Apple TV 4K: New $179 Apple streamer adds HDR, better gaming
To embed this piece of audio in your site, please use this code: X Listen Florian MartinHarris County Sheriff-elect Ed Gonzalez wants to end the 287(g) program because he deems it can violate due process and it is an unnecessary strain on the resources of the Sheriff’s Office.Texas Lieutenant Governor Dan Patrick supports a bill banning so-called sanctuary cities, which are communities that don’t fully cooperate with the federal government in turning over undocumented immigrants, but the next Harris County Sheriff wants to work less with the feds.Harris County Sheriff-elect Ed Gonzalez wants to eliminate the 287(g) program, by which the Sheriff’s Office alerts immigration authorities when they have undocumented immigrants in the county jail.Gonzalez argues the program can violate due process and it is an unnecessary strain on the resources of the Sheriff’s Office.He is also worried about distrust because immigrant communities get the impression that “the Police are now basically deportation agents.”Additionally, Gonzalez argues the program can lead to racial profiling, but some disagree.That is the case of Chris Chmielenski, director of content and activism at NumbersUSA, a group based in Virginia that advocates for reducing the levels of legal immigration to the United States and ending illegal immigration.“I don’t think the intent of the program is to single out people who may be in the country illegally. I think the intent of the program is just to help assist the federal government in enforcement of immigration laws,” Chmielenski says.So, what do two top politicians in greater Houston think about eliminating the 287(g)?Harris County Judge Ed Emmett says he didn’t follow “any of the political campaign so, no, I have no comment.”And Houston Mayor Sylvester Turner comments he will leave that “concern” to the County.Doing away with the program could mean trouble for Harris County because Patrick says eliminating sanctuary cities is one of his priorities for the upcoming session of the Texas Legislature.Republican State Senator Charles Perry has already introduced a bill which requires that city and county jails cooperate with immigration authorities and, if it becomes law, the State could deny funding for those that don’t comply.An example of that funding is the one that pays for some law enforcement programs, according to a person familiar with the bill.Gonzalez acknowledges he is concerned about possible punishment by the State if he eliminates the 287(g), but he hopes things will not come to that because of the political negotiations in Austin.“There’ll be strong dialogue on both sides of it,” Gonzalez notes “and I hope that we could move away from regressive type of policies that are impactful, especially to one large segment of the community, which is the Latino community in this case.”Gonzalez takes office next January. 00:00 /02:26 Share
© 2015 Phys.org Citation: Synthesis and characterization of an important intermediate for biocatalysts (2015, March 19) retrieved 18 August 2019 from https://phys.org/news/2015-03-synthesis-characterization-important-intermediate-biocatalysts.html Cytochrome P450 Oxidase (CYP2C9). Credit: Wikipedia/CC BY-SA 3.0 (Phys.org)—Cytochrome P450 (CYP) is sometimes referred to as the “Rosetta Stone” of iron-containing oxygenases, because of its ubiquity as a biocatalyst for various reactions, including drug metabolism and synthesis of biological molecules. Importantly, CYP catalyzes carbon-hydrogen hydroxylation reactions, cleaving some of the most difficult carbon-hydrogen bonding structures. While CYP is well studied, scientists are eager to understand the ferryl intermediates formed during hydroxylation in an effort to fine-tune catalytic reactions as well as seek out other biocatalysts to react with carbon-hydrogen bonds that are typically unreactive. Apolipoprotein(a): A natural regulator of inflammation More information: “Heme-thiolate ferryl of aromatic peroxygenase is basic and reactive” Xiaoshi Wang, Rene Ullrich, Marticn Hofrichter, and John T. Groves, www.pnas.org/cgi/doi/10.1073/pnas.1503340112AbstractA kinetic and spectroscopic characterization of the ferryl intermediate (APO-II) from APO, the heme-thiolate peroxygenase from Agrocybe aegerita, is described. APO-II was generated by reaction of the ferric enzyme with metachloroperoxybenzoic acid in the presence of nitroxyl radicals and detected with the use of rapid-mixing stopped-flow UV-visible (UV-vis) spectroscopy. The nitroxyl radicals served as selective reductants of APO-I, reacting only slowly with APO-II. APO-II displayed a split Soret UV-vis spectrum (370 nm and 428 nm) characteristic of thiolate ligation. Rapid-mixing, pH-jump spectrophotometry revealed a basic pKa of 10.0 for the FeIV−O−H of APO-II, indicating that APO-II is protonated under typical turnover conditions. Kinetic characterization showed that APO-II is unusually reactive toward a panel of benzylic C−H and phenolic substrates, with second-order rate constants for C−H and O−H bond scission in the range of 10–107 M−1⋅s−1. Our results demonstrate the important role of the axial cysteine ligand in increasing the proton affinity of the ferryl oxygen of APO intermediates, thus providing additional driving force for C−H and O−H bond scission. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Researchers have recently found that aromatic peroxygenases (APO), a fungus-based heme thiolate protein, can catalyze the oxygenation of aliphatic and aromatic hydrocarbons. Based on the products from these reactions, APO seems to behave similarly to CYP, although it apparently is more stable over a larger range of pH. This provides an opportunity to study the hydroxylation reaction mechanism of an analogous molecule to CYP that could serve as another potential biocatalyst. Xiaoshi Wang and John T. Groves from the Department of Chemistry at Princeton University report the isolation and characterization of APO-II, an important intermediate in hydroxylation, in the Proceedings of the National Academy of Sciences.Previous work by Groves’ group has shown that APO, derived from Agrocybe aegerita forms an oxoiron (IV) porphyrin radical cation (APO-I) that can be detected by UV-visible spectroscopy. The current work, isolates APO-II, a reduced form of APO-I. APO has an OH2 group coordinated to the central iron atom. Oxidation, using mCPBA yields an oxidized, Fe=O, interaction. Wang and Groves sought to isolate APO-II, which has an OH group coordinated to iron, via a one electron reduction reaction.Wang and Groves began by oxidizing APO using mCPBA, and then determined that the reduction of APO-I using a nitroxyl radical would provide APO-II. They tested their nitroxyl radical candidates using a model system, ensuring that they would get complete conversion from the oxidized to the reduced intermediate, and landed on 3-carboxy-PROXYL as the best reducing agent.UV-visible spectroscopy confirmed that they made APO-II using a single-mixing stopped flow experiment. They were also able to confirm that APO-II was formed via the direct reduction of APO-I using a double-mixing step. Kinetic studies indicated that APO-II remained in solution for 0.5 seconds and has an approximate decay rate of 1 sec-1, making it an intermediate that is stable enough to allow for further study.Because APO is stable at a wide range of pH values, pH 7.0 to pH 12, Wang and Groves were able to determine the pKa value of the proton on the hydroxyl group of APO-II using titration with buffer solutions and characterization with UV-visible spectroscopy. They found that the pKa for the hydroxyl proton was approximately 10, indicating that the molecule was protonated at a pH below 10. They also determined that the sulfur remained bound to the iron upon deprotonation at high pH.Finally, Wang and Groves investigated the reactivity of various substrates in an APO-II catalyzed hydroxylation reaction. They found that APO-II has a surprisingly high reactivity toward phenols and substrates with relatively weak benzylic carbon-hydrogen bonds. The high reactivity with phenols was unexpected because analogous peroxidases typically do not react as quickly. Additionally, according to the kinetic data, APO-II seems to be a milder oxidant compared to APO-I, which was expected based on other systems.This research provides insight into CYP-like reactivity by investigating a key intermediate in the hydroxylation reaction. According to Dr. Groves, “The surprisingly high reactivity of APO-II toward weak C-H bonds may facilitate the development of more selective biocatalysts.” Journal information: Proceedings of the National Academy of Sciences Explore further